EDUCATION AND TRAINING IN THE CARE
AND USE OF LABORATORY ANIMALS (March 2002, rev May 2003, July 2008, Feb 2012)
The privilege of using animals in research is subject to three
Congressional Acts: the Health Research Extension Act (Public Law 99-158), the Food
Security Act (Public Law 99-198), and the Animal Welfare Act (AWA) [7 U.S.C. 2131-2156].
The AWA details requirements for the care and use of animals in research, testing and education.
Specifically, Subpart C, Section 2.32, Personnel Qualification, requires that:
- It shall be the responsibility of the research facility
to ensure that all scientists, research technicians, animal technicians, and other
personnel involved in animal care, treatment and use are qualified to perform their duties.
This responsibility shall be fulfilled in part through the provision of training and
instruction to those personnel.
- Training and instruction shall be made available, and qualifications
of personnel reviewed, with sufficient frequency to fulfill the research facility's
responsibilities under this section.
Distribution of Responsibility
It is the Principal Investigator's responsibility
to assure that his or her staff are trained and qualified. The
Institutional Animal Care and
Use Committee (IACUC) is responsible for the oversight and content
of the UCSF Animal Use Training Program. The IACUC
training staff conducts and documents training programs that
meet federal requirements, and works with Laboratory
Animal Resource Center and individual investigators to develop
and document their own staff training.
Basis for Training Program
In 1991, the Committee on Education Programs in Laboratory Animal
Science (Institute of Laboratory Animal Research, Commission of
Life Sciences, National Research Council) published its report
entitled, Education and Training in the Care and Use of Laboratory
Animals - A Guide for Developing Institutional Programs. This
document is the basis for UCSF's animal care training program.
UCSF Personnel Affected
The following UCSF personnel must complete the required training
in the care and use of animals in research and instruction if
they have contact with any living vertebrate animals:
- Research technicians and research animal technicians
- Medical students, fellows, and residents
- Summer students
- Visiting scholars
- Other individuals involved in the care and handling of animals
- PIs and Co-PIs on Animal Use Protocols, even if those individuals
will not have direct animal contact.
In addition, sufficiently detailed information
on the experience and training of each individual involved must
be included on the IACUC-approved protocol before any hands-on
work may be done.
The UCSF Animal Care and Use Training Program consists of six components:
- Basic Ethical and Regulatory Requirements online modules
- Species-Specific Training
- Laboratory-provided Training
- Other IACUC-Mandated Training
- Periodic Retraining
- LARC Facility orientation
IACUC staff, in conjunction with various individuals and
user groups identified by the IACUC, has developed the content
These programs will be periodically reviewed and updated to reflect
any relevant changes in regulatory requirements and/or IACUC
cards will not be activated nor keys issued for individual access
to LARC animal facilities until IACUC-mandated training requirements
and a LARC facility orientation have been completed.
1. Basic Regulatory and Ethical Requirements
Effective June 1, 2003, ALL animal users must take one or both
online training modules as appropriate, regardless of prior training.
The core module, BRER I,
is mandatory for all users listed as having animal contact on an active IACUC protocol. It covers
- Ethical and scientific issues related to animal research;
- Laws, regulations, and policies related to animal research;
- Methods whereby animal care and treatment are reported;
- Responsibilities of the IACUC, research and veterinary staff;
- Alternatives to the use of animals and to the procedures planned;
- Pain and discomfort, anesthetics, and analgesics;
- General safety, health and environmental considerations (Zoonoses).
A BRER I test out option is available. If the test-out is passed, you will not have to take the BRER I course. If you fail the test-out, you will have to register for BRER I.
The BRER II module is required for all personnel working with anesthetic agents and/or performing surgery or post-surgical care. A BRER II test out option is also available. If the test-out is passed, you will not have to take the BRER II course. If you fail the test-out, you will have to register for BRER II.
Both modules include tests that must be passed to receive credit
for the course.
2. Species-Specific Training
In addition to the basic training described
above, effective January
1, 2000, species-specific training will be required for all
personnel who will be in
direct contact with animals, as follows:
Any new user with less than 12 months of experience
in the specific species must attend the appropriate species-specific
that the safety component of sheep and primate species-specific
training is UCSF-specific and is required of all new sheep
or primate users regardless of prior experience with these
species on other campuses.
The IACUC will determine during the review process the need
for, and extent of, training for others listed on the protocol,
and for additional hands-on or similar training (e.g., observation
by LARC staff), and include any requirement as a condition
of IACUC approval of the protocol.
specific content and degree of detail will vary depending on the
knowledge, previous experience and expertise of the target audience.
The modules will contain, as appropriate:
- Selection and procurement of animals;
- Husbandry and care;
- Handling and restraint;
- Anesthesia, analgesia, peri-operative monitoring, medications;
- Survival surgery and post-surgical care;
- Skill-building for selected procedures (hands-on sessions);
- Identification and records;
- Species-specific euthanasia;
- Species-specific safety, health and environmental considerations; and
- Other specific issues as needed.
3. Laboratory-provided Training
Individual PIs and/or their designates can apply to the IACUC
training staff to conduct and document their own equivalent
of the Species-Specific
training sessions. For approval, such laboratories/investigators
will work with the IACUC to develop the content of the
session and the method for documenting training. IACUC will
maintain a database of individuals approved to provide introductory
in PIs' laboratories.
4. Other IACUC-Mandated Training
As stated above, the IACUC may mandate additional
training for individuals or an entire group if:
During the initial protocol review process, the need for more training
The procedures in the protocol are changed or amended substantially
enough to warrant additional training (e.g., changing from
acute to survival surgery).
The IACUC identifies violations of the protocol due to lack
of understanding of procedures or insufficient training.
5. Periodic Retraining
Effective June 1, 2003 all individuals listed on an
animal research protocol must undergo periodic retraining as prescribed
by the IACUC every three years to retain their privilege to conduct
research involving the use of animals. The retraining modules will be designed
address new, or changes in existing, regulatory or policy requirements.
6. LARC Facility Orientation
For most facilities where animals are housed, new individuals should
meet with the relevant LARC area supervisor or principle technician
to receive orientation for that particular facility.
The IACUC recognizes that UCSF research faculty
are often involved in collaborative efforts with other institutions,
which may include
short-term visitors (a few days to a maximum of 30 days),
and that at times these visitors may need to participate in
study involving animals. The IACUC will grant an exemption to
these individuals if:
- The participant has a minimum of one year
of prior animal use experience in the species involved.
- The UCSF PI/Co-PI forwards a completed
Request for Exemption from IACUC Training form to IACUC
office for review.
- A veterinarian reviews the form and approves
the individual's exemption from training.
- The veterinarian informs the PI /Co-PI of
training exemption approval.
- The veterinarian forwards a copy of the
training exemption approval to the IACUC office to keep
- The PI/Co-PI briefs the short-term participant
in the details of the study and the procedures, and has the
participant read and initial the relevant IACUC-approved protocol.
- The PI/Co-PI directly supervises the individual
during the study, and this is documented by the PI/Co-PI signing
the form and placing it in the PI's central LARC/IACUC Logbook.
Basic Regulatory and Ethical Requirements.
Core and Surgery / Anesthesia modules are available on-line at
the user's convenience.
Rat and Mouse Basic Introductory
training may also be scheduled on-line (class size is limited).
Call 476-2197 for information or Email: email@example.com
Species-Specific Courses for
all other species and any other IACUC-Mandated Training are
scheduled according to demand.
Call 476-2197 for information or Email: firstname.lastname@example.org